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CBD Side Effects

Side Effects And Safety Of CBD

Modified Date: November 9, 2019

The cannabis plant has been used medicinally for over 4,000 years. Until recently, scientists knew little about how the drug works in the human body.  Made illegal in the United States in 1938 by the Marihuana Tax Act, research on the compound was hampered for decades. However, recent legislation has brought cannabis back into the public realm and researchers are hard at work conducting clinical studies that will one day help us to learn more.

CBD - What We Know

What we do know is that there are over 100 chemical compounds in the cannabis sativa plant, and the potential effects of all of these are still largely a mystery.  Two of the main cannabinoids—tetrahydrocannabinol (THC) and CBD— are what has gained the most attention in recent years. These active ingredients in the plant mimic specific molecules created in the brain— a function of what we now call the endocannabinoid system.

Both molecules act in different ways. THC is the psychoactive compound that is responsible for the high that users feel when they smoke pot or take edibles.  It is what people are usually referring to when they talk about medical marijuana. The second compound, CBD is the one with all the hype surrounding it.

CBD is sourced from industrial hemp and has no psychoactive effects, so it is not used recreationally. But it is being used to combat everything from depression to seizures. The main reason for its astounding popularity is that it has very few side effects when compared to synthetic drugs.

Cannabidiol (CBD) oil is the most well-known CBD product, but there are other ways to utilize it as well. Capsules, topicals, edibles, and vape products containing CBD are widely available.

CBD Information From The World Health Organization

In June of 2018, The World Health Organization published a 27-page report about CBD.

Out of their findings came some important statements which we can sum up in four sentences:

  • The preliminary evidence collected by WHO suggests that CBD may be beneficial for treating several medical conditions.
  • There have been no negative public health effects linked to CBD.
  • CBD is well-tolerated by most people and its safety profile is excellent.
  • Reported side effects are likely due to interactions between CBD and a patient’s other prescriptions.

Can You Overdose On CBD?

No. fatal overdoses of CBD have ever been reported, and people have taken as much as 1550 mg a day with no toxic effects. Compared to over the counter pain and anti-inflammatory medications like Tylenol, for example, the relative safety of CBD is incredible.

What Are Some Of The Potential Side Effects Of CBD?

  • Drowsiness: Many people have reported drowsiness after consuming CBD in high quantities. It has also been said to have a calming sensation when in moderate amounts.  
  • Dry Mouth: Scientists have recently confirmed the presence of cannabinoid receptors in our salivary glands. The dry mouth effect is caused by an interaction between CBD and cannabinoid receptors. The result is the inhibition of secretion of saliva.
  • Low Blood Pressure: consumption of very high doses of CBD has also been reported to prompt a slight drop in blood pressure. This is often associated with mild lightheadedness.
  • Lightheadedness: Some consumers reported experiencing mild feelings of lightheadedness as a result of high doses of CBD.
  • Nausea and Diarrhea: Some people have experience stomach upset after taking CBD. However, Cannabis is also used to treat nausea in people undergoing chemotherapy.

Can CBD Interact With Other Medications?

CBD inhibits an enzyme that can change the effectiveness of certain prescriptions.  The Cytochrome P450 is also found in grapefruit. Some medications are labeled with a grapefruit warning for this reason. If you are taking a drug that carries this warning, it doesn’t necessarily mean you won’t be able to use CBD or that you will have adverse effects. However, you should speak to your doctor before taking It. Several medicines can possibly have an interaction with the cytochrome P450  enzyme:

  • Blood Thinners
  • Antiepileptics
  • Antidepressants
  • Anti-psychotics
  • Benzodiazepines
  • Beta Blockers
  • HIV Antiretrovirals
  • Antihistamines
  • Pain Medications

Studies on the potential role of CBD oil in treating many common health issues, including acne, anxiety disorders, arthritis, chronic pain, depression, and heart disease are promising.  In every study, CBD has been found to be safe. A study published by NCBI in 2001 concluded that CBD does not cause changes to food intake, affect the heart rate, change blood pressure, or alter body temperature. It also does not affect cognitive or psychological functions. 

Can CBD Be Used By Pregnant Women?

There have clinical trials to date on CBD use by pregnant or nursing women. If you are pregnant or lactating. You should speak with your obstetrician before taking CBD.

Can CBD Be Used By Children?

Recently, the FDA  approved a CBD-based drug for the long term treatment of lennox gastaut syndrome and other intractable forms of epilepsy in children.


These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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